It has the following structural formula:Īcetaminophen, 4’-hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. The chemical name is 4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5). Hydrocodone bitartrate is an opioid analgesic and occurs as fine, white crystals or as a crystalline powder. NORCO ® (hydrocodone bitartrate and acetaminophen) is available in tablet form for oral administration. Follow patients for signs and symptoms of respiratory depression and sedation.Limit dosages and durations to the minimum required.Reserve concomitant prescribing of NORCO and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate.Risks From Concomitant Use With Benzodiazepines Or Other CNS DepressantsĬoncomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4, 000 milligrams per day, and often involve more than one acetaminophen - containing product. Īcetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. ![]() Monitor patients receiving NORCO and any Cytochrome P450 3A4 inhibitor or inducer for signs of respiratory depression or sedation. In addition, discontinuation of a concomitantly used C ytochrome P450 3A4 inducer may result in an increase in NORCO plasma concentration s. The concomitant use of NORCO with all C ytochrome P450 3A4 inhibitors may result in an increase in NORCO plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available. Prolonged use of NORCO during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. Īccidental ingestion of NORCO, especially by children, can result in a fatal overdose of NORCO. Monitor for respiratory depression, especially during initiation of NORCO or following a dose increase. Serious, life-threatening, or fatal respiratory depression may occur with use of NORCO.
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